To the problems of modeling the brain ischemia in small animals

In the review article the problems of modeling cerebral ischemia in small mammals are consecrated. The advantages of experimental studies that are based on the similarity of the blood circulation of the brain in humans and animals are indicated. Classification of experimental models for the study of...

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Main Authors: A. N. Stoyanov (Author), S. S. Mashchenko (Author), I. O. Ostapenko (Author), I. K. Bakumenko (Author), S. M. Oleinik (Author), V. Z. Skorobreha (Author)
Format: Book
Published: Kazimierz Wielki University, 2019-02-01T00:00:00Z.
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100 1 0 |a A. N. Stoyanov  |e author 
700 1 0 |a S. S. Mashchenko  |e author 
700 1 0 |a I. O. Ostapenko  |e author 
700 1 0 |a I. K. Bakumenko  |e author 
700 1 0 |a S. M. Oleinik  |e author 
700 1 0 |a V. Z. Skorobreha  |e author 
245 0 0 |a To the problems of modeling the brain ischemia in small animals 
260 |b Kazimierz Wielki University,   |c 2019-02-01T00:00:00Z. 
500 |a 2391-8306 
500 |a 10.5281/zenodo.2589557 
520 |a In the review article the problems of modeling cerebral ischemia in small mammals are consecrated. The advantages of experimental studies that are based on the similarity of the blood circulation of the brain in humans and animals are indicated. Classification of experimental models for the study of acute and chronic disorders of cerebral circulation, mechanisms of their development and preclinical approbation of new drugs is given. The authors indicate that all experimental models of brain ischemia can be divided into two groups: to study risk factors and pathophysiological studies of brain ischemia. And in the second case, the models of focal and global ischemia are described. In conclusion, the authors point out the difficulties and shortcomings of certain methods of ischemia reproduction, which await researchers to solve the above problems. 
546 |a EN 
546 |a ES 
546 |a PL 
546 |a RU 
546 |a UK 
690 |a modeling of brain ischemia, small animal 
690 |a Education 
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690 |a Sports 
690 |a GV557-1198.995 
690 |a Medicine 
690 |a R 
655 7 |a article  |2 local 
786 0 |n Journal of Education, Health and Sport, Vol 9, Iss 2, Pp 500-520 (2019) 
787 0 |n http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6675 
787 0 |n https://doaj.org/toc/2391-8306 
856 4 1 |u https://doaj.org/article/07e4b7f3fdee46bf9dd01b53ebdbc587  |z Connect to this object online.