Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• المؤلفون الرئيسيون: Kristoffer K. Hendel (مؤلف), Charlotte Bagger (مؤلف), Uffe H. Olesen (مؤلف), Christian Janfelt (مؤلف), Steen H. Hansen (مؤلف), Merete Haedersdal (مؤلف), Catharina M. Lerche (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...