Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Prif Awduron: Kristoffer K. Hendel (Awdur), Charlotte Bagger (Awdur), Uffe H. Olesen (Awdur), Christian Janfelt (Awdur), Steen H. Hansen (Awdur), Merete Haedersdal (Awdur), Catharina M. Lerche (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...