Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Hauptverfasser: Kristoffer K. Hendel (Verfasst von), Charlotte Bagger (Verfasst von), Uffe H. Olesen (Verfasst von), Christian Janfelt (Verfasst von), Steen H. Hansen (Verfasst von), Merete Haedersdal (Verfasst von), Catharina M. Lerche (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...