Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Autores principales: Kristoffer K. Hendel (Autor), Charlotte Bagger (Autor), Uffe H. Olesen (Autor), Christian Janfelt (Autor), Steen H. Hansen (Autor), Merete Haedersdal (Autor), Catharina M. Lerche (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...