Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Príomhchruthaitheoirí: Kristoffer K. Hendel (Údar), Charlotte Bagger (Údar), Uffe H. Olesen (Údar), Christian Janfelt (Údar), Steen H. Hansen (Údar), Merete Haedersdal (Údar), Catharina M. Lerche (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...