Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Váldodahkkit: Kristoffer K. Hendel (Dahkki), Charlotte Bagger (Dahkki), Uffe H. Olesen (Dahkki), Christian Janfelt (Dahkki), Steen H. Hansen (Dahkki), Merete Haedersdal (Dahkki), Catharina M. Lerche (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...