Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Linn Leaves in Alloxan-Induced Diabetic Rats

• Main Authors: Basiru O. Ajiboye PhD (Author), Oluwafemi A. Ojo MSc (Author), Olivia S. Akuboh BSc (Author), Okesola M. Abiola MSc (Author), Olajumoke Idowu MSc (Author), Aliyu O. Amuzat MSc (Author)
• Format: Book
• Published: SAGE Publishing, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostasis model assessment-insulin resistance scores, lipid peroxidation concentration, glucose-6-phosphatase activity, and all concentrations of anti-inflammatory studied in alloxan-induced diabetic rats were significantly ( P < .05) reduced with the administration of polyphenolic-rich extract of Syzygium cumini leaves. Also there was significant ( P < .05) increase in glycogen and insulin concentrations, pancreatic β-cell scores, antioxidant enzymes and hexokinase activities, as well as glucose transporter levels in diabetic animals administered with polyphenolic-rich extract of S cumini leaves. The results indicate that S cumini leaves possess anti-hyperglycemic and anti-inflammatory activities.

Item Description

2515-690X
10.1177/2515690X18770630