Paeoniflorin Alleviates Skeletal Muscle Atrophy in Ovariectomized Mice through the ERα/NRF1 Mitochondrial Biogenesis Pathway

• Main Authors: Ki-Sun Park (Author), Hyungjun Kim (Author), Hye Jin Kim (Author), Kang-In Lee (Author), Seo-Young Lee (Author), Jieun Kim (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2022-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Muscle atrophy in postmenopausal women is caused by estrogen deficiency and a variety of inflammatory factors, including tumor necrosis factor alpha (TNFα). Paeoniflorin (PNF), a natural compound with anti-inflammatory properties, improves estradiol synthesis. Here, we demonstrate that PNF inhibits...