Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis

• Main Authors: Matsuda Akihisa (Author), Kishi Taro (Author), Jacob Asha (Author), Aziz Monowar (Author), Wang Ping (Author)
• Format: Book
• Published: BMC, 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>A previous meta-analysis reported a positive association between an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (<it>ACE</it>) and the risk of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Here, we updated this meta-analysis and additionally assessed the association of this polymorphism with ALI/ARDS mortality.</p> <p>Methods</p> <p>We searched electronic databases through October 2011 for the terms "angiotensin-converting enzyme gene", "acute lung injury", and "acute respiratory distress syndrome," and reviewed all studies that reported the relationship of the I/D polymorphism in <it>ACE</it> with ALI/ARDS in humans. Seven studies met the inclusion criteria, comprising 532 ALI/ARDS patients, 3032 healthy controls, and 1432 patients without ALI/ARDS. We used three genetic models: the allele, dominant, and recessive models.</p> <p>Results</p> <p>The <it>ACE</it> I/D polymorphism was not associated with susceptibility to ALI/ARDS for any genetic model. However, the <it>ACE</it> I/D polymorphism was associated with the mortality risk of ALI/ARDS in Asian subjects ( <it>P</it>_allele < 0.0001, <it>P</it>_dominant = 0.001, <it>P</it>_recessive = 0.002). This finding remained significant after correction for multiple comparisons.</p> <p>Conclusions</p> <p>There is a possible association between the <it>ACE</it> I/D polymorphism genotype and the mortality risk of ALI/ARDS in Asians.</p>

Item Description

10.1186/1471-2350-13-76
1471-2350