The possible pathogenesis of cemento-osseous dysplasia: A case series and discussion
Cemento-osseous dysplasias (COD) are peculiar jawbone lesions. They arise in the tooth-bearing areas, mostly in the mandibles of women, and have no known occurrence in the other bones. Neural crest-derived periodontal fibroblasts may form disorganized cemento-osseous structures that have been observ...
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| Main Authors: | , , |
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| Format: | Book |
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Elsevier,
2021-07-01T00:00:00Z.
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| Summary: | Cemento-osseous dysplasias (COD) are peculiar jawbone lesions. They arise in the tooth-bearing areas, mostly in the mandibles of women, and have no known occurrence in the other bones. Neural crest-derived periodontal fibroblasts may form disorganized cemento-osseous structures that have been observed to be radiologically sclerotic.We performed a retrospective immunohistochemical study on the tissues of 16 patients diagnosed with COD using biopsy. Some patients displayed a history of bruxism and jaw clenching. The selection of beta-catenin, cyclin D1, nestin, estrogen receptor, tubulin, and integrin antibodies was based on factors that may be pathogenetically significant.COD develops as a consequence of the jawbone-specific cemento-osseous reparative process that far from remodelization. Parafunctional mechanical effects are assumed to form these lesions. |
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| Item Description: | 2667-1476 10.1016/j.adoms.2021.100105 |