The possible pathogenesis of cemento-osseous dysplasia: A case series and discussion

• Main Authors: Ömer Günhan (Author), Devrim Kahraman (Author), Ülker Karagece Yalçın (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2667-1476; 10.1016/j.adoms.2021.100105
• Keywords: Cemento-osseous dysplasia; Fibro-osseous lesion; Osseous dysplasia; Hypercementosis; Periodontal fibroblast; Internal medicine; RC31-1245; Surgery; RD1-811
• Source: Advances in Oral and Maxillofacial Surgery, Vol 3, Iss , Pp 100105- (2021)

Cemento-osseous dysplasias (COD) are peculiar jawbone lesions. They arise in the tooth-bearing areas, mostly in the mandibles of women, and have no known occurrence in the other bones. Neural crest-derived periodontal fibroblasts may form disorganized cemento-osseous structures that have been observed to be radiologically sclerotic.We performed a retrospective immunohistochemical study on the tissues of 16 patients diagnosed with COD using biopsy. Some patients displayed a history of bruxism and jaw clenching. The selection of beta-catenin, cyclin D1, nestin, estrogen receptor, tubulin, and integrin antibodies was based on factors that may be pathogenetically significant.COD develops as a consequence of the jawbone-specific cemento-osseous reparative process that far from remodelization. Parafunctional mechanical effects are assumed to form these lesions.