Targeting purine metabolism in ovarian cancer

• Main Authors: Jingchun Liu (Author), Shasha Hong (Author), Jiang Yang (Author), Xiaoyi Zhang (Author), Ying Wang (Author), Haoyu Wang (Author), Jiaxin Peng (Author), Li Hong (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in these enzymes leads to excessive cell pro...