Haplotyping by linked-read sequencing (HLRS) of the genetic disease carriers for preimplantation genetic testing without a proband or relatives

• Main Authors: Qing Li (Author), Yan Mao (Author), Shaoying Li (Author), Hongzi Du (Author), Wenzhi He (Author), Jianchun He (Author), Lingyin Kong (Author), Jun Zhang (Author), Bo Liang (Author), Jianqiao Liu (Author)
• Format: Book
• Published: BMC, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In order to mitigate the risk of allele dropout (ADO) and ensure the accuracy of preimplantation genetic testing for monogenic disease (PGT-M), it is necessary to construct parental haplotypes. Typically, haplotype resolution is obtained by genotyping multiple polymorphic markers...