Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases.

• Main Authors: Madhu K Sundaraneedi (Author), Bemnet A Tedla (Author), Ramon M Eichenberger (Author), Luke Becker (Author), Darren Pickering (Author), Michael J Smout (Author), Siji Rajan (Author), Phurpa Wangchuk (Author), F Richard Keene (Author), Alex Loukas (Author), J Grant Collins (Author), Mark S Pearson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis affects over 200 million people and there are concerns whether the current chemotherapeutic control strategy (periodic mass drug administration with praziquantel (PZQ)-the only licenced anti-schistosome compound) is sustainable, necessitating the development of new drugs.We investiga...