Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons

• Main Authors: Langeslag Michiel (Author), Constantin Cristina E (Author), Andratsch Manfred (Author), Quarta Serena (Author), Mair Norbert (Author), Kress Michaela (Author)
• Format: Book
• Published: SAGE Publishing, 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Oncostatin M (OSM) is a member of the interleukin-6 cytokine family and regulates eg. gene activation, cell survival, proliferation and differentiation. OSM binds to a receptor complex consisting of the ubiquitously expressed signal transducer gp130 and the ligan...