A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

• Main Authors: Pedro Martín-Acosta (Author), Qianli Meng (Author), John Klimek (Author), Ashok P. Reddy (Author), Larry David (Author), Stefanie Kaech Petrie (Author), Bingbing X. Li (Author), Xiangshu Xiao (Author)
• Formato: Livro
• Publicado em: Elsevier, 2022-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge, unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approac...