miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster

• Main Authors: Yan Sweat (Author), Ryan J. Ries (Author), Mason Sweat (Author), Dan Su (Author), Fan Shao (Author), Steven Eliason (Author), Brad A. Amendt (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anaplastic thyroid cancer (ATC) is an aggressive, highly metastatic cancer that expresses high levels of the microRNA (miR)-17-92 cluster. We employ an miR inhibitor system to study the function of the different miRs within the miR-17-92 cluster based on seed sequence homology in the ATC SW579 cell...