Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose

• Main Authors: Aprilita Rina Yanti Eff (Author), Reza Ayu Pertiwi (Author), Hermanus Ehe Hurit (Author), Sri Teguh Rahayu (Author), Yonatan Eden (Author)
• Format: Book
• Published: Universitas Indonesia, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: https://doi.org/10.7454/psr.v9i1.1252; 2407-2354; 2477-0612
• Keywords: fructose; jamu; kidney; glutathione; malondialdehyde; superoxide dismutase; Pharmacy and materia medica; RS1-441; Therapeutics. Pharmacology; RM1-950
• Source: Pharmaceutical Sciences and Research, Vol 9, Iss 1, Pp 42-50 (2022)

Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.