Vitamin K deficiency: a case report and review of current guidelines

Abstract Background Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB). Case presentation We present the case of a 2 months...

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Main Authors: Maria Rosaria Marchili (Author), Elisa Santoro (Author), Alessandra Marchesi (Author), Simona Bianchi (Author), Lelia Rotondi Aufiero (Author), Alberto Villani (Author)
Format: Book
Published: BMC, 2018-03-01T00:00:00Z.
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Summary:Abstract Background Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB). Case presentation We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery. Conclusions Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.
Item Description:10.1186/s13052-018-0474-0
1824-7288