Alteration to the SWI/SNF complex in human cancers
The SWI/SNF complex is a key catalyst for gene expression and regulates a variety of pathways, many of which have anticancer roles. Its central roles in cellular growth control, DNA repair, differentiation, cell adhesion and development are often targeted, and inactivated, during cancer development...
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Frontiers Media S.A.,
2011-12-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_09a85eb29fda4ea797f4f09599aa8e50 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Vanessa S. Gordon |e author |
| 700 | 1 | 0 | |a Colin Rogers |e author |
| 700 | 1 | 0 | |a David Reisman |e author |
| 245 | 0 | 0 | |a Alteration to the SWI/SNF complex in human cancers |
| 260 | |b Frontiers Media S.A., |c 2011-12-01T00:00:00Z. | ||
| 500 | |a 10.4081/oncol.2010.89 | ||
| 500 | |a 1970-5557 | ||
| 500 | |a 1970-5565 | ||
| 520 | |a The SWI/SNF complex is a key catalyst for gene expression and regulates a variety of pathways, many of which have anticancer roles. Its central roles in cellular growth control, DNA repair, differentiation, cell adhesion and development are often targeted, and inactivated, during cancer development and progression. In this review, we will discuss what is known about how SWI/SNF is inactivated, and describe the potential impact of abrogating this complex. BRG1 and BRM are the catalytic subunits which are essential for SWI/SNF function, and thus, it is not surprising that they are lost in a variety of cancer types. As neither gene is mutated when lost, the mechanism of suppression, as well as the impact of potential gene activity restoration, are reviewed. | ||
| 546 | |a EN | ||
| 690 | |a Brahma related gene 1 (BRG1) - Brahma (BRM) - SWI/SNF complex - Tumor suppressor - Epigenetic - Retinoblastoma protein - Subunits - Cancer progression | ||
| 690 | |a Other systems of medicine | ||
| 690 | |a RZ201-999 | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Oncology Reviews, Vol 4, Iss 2 (2011) | |
| 787 | 0 | |n http://www.oncologyreviews.org/index.php/or/article/view/52 | |
| 787 | 0 | |n https://doaj.org/toc/1970-5557 | |
| 787 | 0 | |n https://doaj.org/toc/1970-5565 | |
| 856 | 4 | 1 | |u https://doaj.org/article/09a85eb29fda4ea797f4f09599aa8e50 |z Connect to this object online. |