Sirtuins & disease: the road ahead

• Main Authors: Vincenzo eCarafa (Author), Angela eNebbioso (Author), Lucia eAltucci (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirtuins represent a promising new class of conserved histone deacetylases, originally identified in yeast. The activity of the sirtuin (SirT) family - made up of seven members (SirT1-7) - is NAD+ dependent. Sirtuins target a wide range of cellular proteins in nucleus, cytoplasm and mitochondria for...