Bioactive Diterpenes, Norditerpenes, and Sesquiterpenes from a Formosan Soft Coral <i>Cespitularia</i> sp.

• Main Authors: You-Cheng Lin (Author), Chi-Chien Lin (Author), Yi-Chia Chu (Author), Chung-Wei Fu (Author), Jyh-Horng Sheu (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Chemical investigation of the soft coral <i>Cespitularia</i> sp. led to the discovery of twelve new verticillane-type diterpenes and norditerpenes: cespitulins H-O (<b>1</b>-<b>8</b>), one cyclic diterpenoidal amide cespitulactam L (<b>9</b>), norditerpenes cespitulin P (<b>10</b>), cespitulins Q and R (<b>11</b> and <b>12</b>), four new sesquiterpenes: cespilins A-C (<b>13</b>-<b>15</b>) and cespitulolide (<b>16</b>), along with twelve known metabolites. The structures of these metabolites were established by extensive spectroscopic analyses, including 2D NMR experiments. Anti-inflammatory effects of the isolated compounds were studied by evaluating the suppression of pro-inflammatory protein tumor necrosis factor-α (TNF-α) and nitric oxide (NO) overproduction, and the inhibition of the gene expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in lipopolysaccharide-induced dendritic cells. A number of these metabolites were found to exhibit promising anti-inflammatory activities.

Item Description

10.3390/ph14121252
1424-8247