Folic Acid Improves Parkin-Null <i>Drosophila</i> Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and Glutathione Redox Equilibrium

• Main Authors: Katherine L. Houlihan (Author), Petros P. Keoseyan (Author), Amber N. Juba (Author), Tigran Margaryan (Author), Max E. Voss (Author), Alexander M. Babaoghli (Author), Justin M. Norris (Author), Greg J. Adrian (Author), Artak Tovmasyan (Author), Lori M. Buhlman (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-10-01T00:00:00Z.
• Fag: article
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Loss-of-function parkin mutations cause oxidative stress and degeneration of dopaminergic neurons in the substantia nigra. Several consequences of parkin mutations have been described; to what degree they contribute to selective neurodegeneration remains unclear. Specific factors initiating excessiv...