Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice

• Main Authors: Margarita Vida (Author), Ana Luisa Gavito (Author), Francisco Javier Pavón (Author), Dolores Bautista (Author), Antonia Serrano (Author), Juan Suarez (Author), Sergio Arrabal (Author), Juan Decara (Author), Miguel Romero-Cuevas (Author), Fernando Rodríguez de Fonseca (Author), Elena Baixeras (Author)
• Format: Book
• Published: The Company of Biologists, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are elevated in chronic liver diseases, including fatty...