Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling

• Main Authors: Qiang Zheng (Author), Hang Zhao (Author), Dong Jia (Author), Xu Han (Author), Zhenning Liu (Author), Min Zhao (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2021-01-01T00:00:00Z.
• Fag: article
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Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefined. This study was aimed at understanding the rol...