Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide

• Main Authors: Zhe Zhang (Author), Zuyi Chen (Author), Cheng Li (Author), Zhenyu Xiao (Author), Yuan Luo (Author), Xiaochen Pan (Author), Liang Xu (Author), Xuesong Feng (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense oligonucleotides (ASONs) have proven potential for the treatment of various diseases. However, their limited bioavailability restricts their clinical application. New structures with improved enzyme resistance stability and efficient drug delivery are needed. In this work, we propose a nov...