Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme
B-friedoolean-5-ene-3-β-ol (1), β-sitosterol (2), stigmasta-5,22,25-trien-3-β-ol (3), betulinic acid (4), and 5-hydroxy-6,7,4'-trimethoxyflavone (5) were isolated from the aerial parts of Clerodendrum inerme L. (Verbenaceae). Their structures were established based on analyses of physical and s...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Faculty of Pharmacy, Cairo University,
2014-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | B-friedoolean-5-ene-3-β-ol (1), β-sitosterol (2), stigmasta-5,22,25-trien-3-β-ol (3), betulinic acid (4), and 5-hydroxy-6,7,4'-trimethoxyflavone (5) were isolated from the aerial parts of Clerodendrum inerme L. (Verbenaceae). Their structures were established based on analyses of physical and spectroscopic data. Compounds 1, 4, and 5 were isolated for the first time from the plant. C. inerme L. was known as a rich source of terpenes, sterols, and phenolic compounds, so the antioxidant and anti-inflammatory activities were evaluated. The total methanolic extract (TME) and compound 5 showed scavenging activity with maximum inhibition of 61.84% for TME (100 μg/mL) and 37.19% for 5 (20 μM), respectively, using DPPH assay. In addition, the TME exhibited anti-inflammatory activity more than indomethacin at dose 200 mg/kg using the formalin induced hind paw edema method. |
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| Item Description: | 1110-0931 10.1016/j.bfopcu.2014.05.002 |