SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles

• Autori principali: Ignacio A. Gallardo (Autore), Daniel A. Todd (Autore), Stella T. Lima (Autore), Jonathan R. Chekan (Autore), Norman H. Chiu (Autore), Ethan Will Taylor (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Associations between dietary selenium status and the clinical outcome of many viral infections, including SARS-CoV-2, are well established. Multiple independent studies have documented a significant inverse correlation between selenium status and the incidence and mortality of COVID-19. At the molec...