Serial Interval and Generation Interval for Imported and Local Infectors, Respectively, Estimated Using Reported Contact-Tracing Data of COVID-19 in China

• Main Authors: Menghui Li (Author), Kai Liu (Author), Yukun Song (Author), Ming Wang (Author), Jinshan Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2296-2565; 10.3389/fpubh.2020.577431
• Keywords: COVID-19; generation interval; imported infection; local infection; serial interval; Public aspects of medicine; RA1-1270
• Source: Frontiers in Public Health, Vol 8 (2021)

The emerging virus, COVID-19, has caused a massive outbreak worldwide. Based on the publicly available contact-tracing data, we identified 509 transmission chains from 20 provinces in China and estimated the serial interval (SI) and generation interval (GI) of COVID-19 in China. Inspired by different possible values of the time-varying reproduction number for the imported cases and the local cases in China, we divided all transmission events into three subsets: imported (the zeroth generation) infecting 1st-generation locals, 1st-generation locals infecting 2nd-generation locals, and other transmissions among 2+. The corresponding SI (GI) is respectively denoted as SI10(GI10), SI21 (GI21), and SI3+2+(GI3+2+). A Bayesian approach with doubly interval-censored likelihood is employed to fit the distribution function of the SI and GI. It was found that the estimated SI10=6.52 (95% CI:5.96-7.13), SI21=6.01 (95%CI:5.44-6.64), SI3+2+=4.39 (95% CI:3.74-5.15), and GI10=5.47 (95% CI:4.57-6.45), GI21=5.01 (95% CI:3.58-7.06), GI3+2+=4.25 (95% CI:2.82-6.23). Thus, overall both SI and GI decrease when generation increases.