Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

• Main Authors: Pengfei Xu (Author), Joy C. Yang (Author), Shu Ning (Author), Bo Chen (Author), Christopher Nip (Author), Qiang Wei (Author), Liangren Liu (Author), Oleta T. Johnson (Author), Allen C. Gao (Author), Jason E. Gestwicki (Author), Christopher P. Evans (Author), Chengfei Liu (Author)
• Format: Knjiga
• Izdano: Elsevier, 2023-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Ubiquitin proteasome activity is suppressed in enzalutamide resistant prostate cancer cells, and the heat shock protein 70/STIP1 homology and U-box-containing protein 1 (HSP70/STUB1) machinery are involved in androgen receptor (AR) and AR variant protein stabilization. Targeting HSP70 could be a via...