Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer

• Main Authors: Jun Young Park (Author), Ye Lim Cho (Author), Ju Ri Chae (Author), Sung Hwan Moon (Author), Won Gil Cho (Author), Yun Jung Choi (Author), Soo Jin Lee (Author), Won Jun Kang (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gemcitabine has been considered a first-line chemotherapy agent for the treatment of pancreatic cancer. However, the initial response rate of gemcitabine is low and chemoresistance occurs frequently. Aptamers can be effectively internalized into cancer cells via binding to target molecules with high...