Host-Guest Complexation of Itraconazole with Cyclodextrins for Bioavailability Enhancement

• Main Authors: Lenuţa-Maria Şuta (Author), Amalia Ridichie (Author), Adriana Ledeţi (Author), Claudia Temereancă (Author), Ionuţ Ledeţi (Author), Delia Muntean (Author), Matilda Rădulescu (Author), Renata-Maria Văruţ (Author), Claudia Watz (Author), Florentin Crăineanu (Author), Denisa Ivan (Author), Gabriela Vlase (Author), Lavinia Stelea (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Itraconazole is an antifungal agent included in the triazole pharmacological classification that belongs to the BCS class II, characterized by a low solubility in an aqueous medium (of 1 ng/mL, at neutral pH), which is frequently translated in a low oral bioavailability but with a high permeability....