Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review
Ameena Mohammed,1 Arunasree M Kalle,2 Pallu Reddanna2 1Department of Biological Science, Indian Institute of Science Education and Research Kolkata, Nadia, West Bengal, 741246, India; 2Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, IndiaCorresponde...
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Dove Medical Press,
2022-07-01T00:00:00Z.
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| 100 | 1 | 0 | |a Mohammed A |e author |
| 700 | 1 | 0 | |a Kalle AM |e author |
| 700 | 1 | 0 | |a Reddanna P |e author |
| 245 | 0 | 0 | |a Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review |
| 260 | |b Dove Medical Press, |c 2022-07-01T00:00:00Z. | ||
| 500 | |a 1178-7031 | ||
| 520 | |a Ameena Mohammed,1 Arunasree M Kalle,2 Pallu Reddanna2 1Department of Biological Science, Indian Institute of Science Education and Research Kolkata, Nadia, West Bengal, 741246, India; 2Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, IndiaCorrespondence: Pallu Reddanna; Arunasree M Kalle, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, TS, 500046, India, Tel +91 4023134542, Fax +91 4023134120, Email prsl@uohyd.ac.in; arunasreemk@uohyd.ac.inAbstract: Severe Corona Virus Disease is characterized by angiocentric inflammation of lungs and cytokine storm leading to potentially fatal multiple organ failure. Several studies have shown the high levels of pro-inflammatory cytokines, indicative of a poor prognosis in COVID-19. Eicosanoids play an important role in the induction of inflammation and cytokine production, while anti-inflammatory and pro-resolving properties of some eicosanoic acid derivatives enable inflamed tissues to return to homeostasis through the resolution of inflammation by aiding the clearance of cell debris and downregulation of pro-inflammatory stimulants. This review attempts to provide an overall insight on the eicosanoids synthesis and their role in the resolution of inflammation in the context of Corona Virus infection.Keywords: COVID-19, lipid mediators of inflammation, polyunsaturated fatty acids, cyclooxygenases, lipoxygenases, cytochrome P450, eicosanoids | ||
| 546 | |a EN | ||
| 690 | |a covid-19 | ||
| 690 | |a lipid mediators of inflammation | ||
| 690 | |a polyunsaturated fatty acids | ||
| 690 | |a cyclooxygenases | ||
| 690 | |a lipoxygenases | ||
| 690 | |a cytochrome p450 | ||
| 690 | |a eicosanoids | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 690 | |a Therapeutics. Pharmacology | ||
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| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Inflammation Research, Vol Volume 15, Pp 4349-4358 (2022) | |
| 787 | 0 | |n https://www.dovepress.com/managing-sars-cov2-infections-through-resolution-of-inflammation-by-ei-peer-reviewed-fulltext-article-JIR | |
| 787 | 0 | |n https://doaj.org/toc/1178-7031 | |
| 856 | 4 | 1 | |u https://doaj.org/article/0b24f48129e9498ca83c4b3d0b5b4529 |z Connect to this object online. |