Downregulation of tumor-suppressor gene LHX6 in cancer: a systematic review

Introduction. LIM Homeobox 6 (LHX6) encodes a LIM homeodomain transcription factor, contributes to tissue development and morphogenesis, and is mostly expressed in medial ganglionic eminence and odontogenic mesenchyme. However, it has been reported to play a role in cancer progression. This narrativ...

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Main Authors: Nathalia Evelyn (Author), Theardy Madelaine Skolastika (Author), Elvira Sharleen (Author), Rosellinny Graciella (Author), Liyanto Andrew Steven (Author), Utama Michael Putra (Author), Sumarpo Anton (Author)
Format: Book
Published: Sciendo, 2018-09-01T00:00:00Z.
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Summary:Introduction. LIM Homeobox 6 (LHX6) encodes a LIM homeodomain transcription factor, contributes to tissue development and morphogenesis, and is mostly expressed in medial ganglionic eminence and odontogenic mesenchyme. However, it has been reported to play a role in cancer progression. This narrative review summarizes literatures that emphasize the molecular regulation of LHX6 in tumorigenesis.
Item Description:2501-062X
10.2478/rjim-2018-0008