Metabolic Memory in Diabetes - Mechanistic Insights and the Impact of Cardiovascular Medication
The prevalence of diabetes mellitus is increasing worldwide. Endothelial dysfunction plays a critical role in the pathophysiology of diabetes-related vascular complications. Several studies have shown that restoring blood glucose levels failed to reduce the incidence of major cardiovascular events i...
I tiakina i:
| Ngā kaituhi matua: | , , , , |
|---|---|
| Hōputu: | Pukapuka |
| I whakaputaina: |
Sciendo,
2021-09-01T00:00:00Z.
|
| Ngā marau: | |
| Urunga tuihono: | Connect to this object online. |
| Ngā Tūtohu: |
Tāpirihia he Tūtohu
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_0b4cb6e6a37d4cd1a87b5c85990f56d2 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Raluca SOSDEAN |e author |
| 700 | 1 | 0 | |a Loredana N. IONICA |e author |
| 700 | 1 | 0 | |a Adrian P. MERCE |e author |
| 700 | 1 | 0 | |a Danina M. MUNTEAN |e author |
| 700 | 1 | 0 | |a Adrian STURZA |e author |
| 245 | 0 | 0 | |a Metabolic Memory in Diabetes - Mechanistic Insights and the Impact of Cardiovascular Medication |
| 260 | |b Sciendo, |c 2021-09-01T00:00:00Z. | ||
| 500 | |a https://doi.org/10.47803/rjc.2021.31.3.511 | ||
| 500 | |a 1220-658X | ||
| 500 | |a 2734-6382 | ||
| 520 | |a The prevalence of diabetes mellitus is increasing worldwide. Endothelial dysfunction plays a critical role in the pathophysiology of diabetes-related vascular complications. Several studies have shown that restoring blood glucose levels failed to reduce the incidence of major cardiovascular events in diabetic population, hence confirming the idea of "metabolic/hyperglycemic memory". The major pathomechanism is, most likely, represented by the overproduction of reactive oxygen species (ROS). The purpose of this minireview is to summarize current knowledge about the mechanisms of metabolic memory and the impact of cardiovascular medication on this phenomenon, respectively. | ||
| 546 | |a EN | ||
| 690 | |a diabetes mellitus | ||
| 690 | |a metabolic memory | ||
| 690 | |a oxidative stress | ||
| 690 | |a cardiovascular medication | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Romanian Journal of Cardiology, Vol 31, Iss 3, Pp 511-516 (2021) | |
| 787 | 0 | |n https://www.romanianjournalcardiology.ro/wp-content/uploads/2021/09/RRC_art-3.pdf | |
| 787 | 0 | |n https://doaj.org/toc/1220-658X | |
| 787 | 0 | |n https://doaj.org/toc/2734-6382 | |
| 856 | 4 | 1 | |u https://doaj.org/article/0b4cb6e6a37d4cd1a87b5c85990f56d2 |z Connect to this object online. |