New Antimicrobials for Gram-Positive Sustained Infections: A Comprehensive Guide for Clinicians

• Main Authors: Davide Carcione (Author), Jari Intra (Author), Lilia Andriani (Author), Floriana Campanile (Author), Floriana Gona (Author), Silvia Carletti (Author), Nicasio Mancini (Author), Gioconda Brigante (Author), Dario Cattaneo (Author), Sara Baldelli (Author), Mattia Chisari (Author), Alessandra Piccirilli (Author), Stefano Di Bella (Author), Luigi Principe (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Antibiotic resistance is a public health problem with increasingly alarming data being reported. Gram-positive bacteria are among the protagonists of severe nosocomial and community infections. The objective of this review is to conduct an extensive examination of emerging treatments for Gram-positive infections including ceftobiprole, ceftaroline, dalbavancin, oritavancin, omadacycline, tedizolid, and delafloxacin. From a methodological standpoint, a comprehensive analysis on clinical trials, molecular structure, mechanism of action, microbiological targeting, clinical use, pharmacokinetic/pharmacodynamic features, and potential for therapeutic drug monitoring will be addressed. Each antibiotic paragraph is divided into specialized microbiological, clinical, and pharmacological sections, including detailed and appropriate tables. A better understanding of the latest promising advances in the field of therapeutic options could lead to the development of a better approach in managing antimicrobial therapy for multidrug-resistant Gram-positive pathogens, which increasingly needs to be better stratified and targeted.

Item Description

10.3390/ph16091304
1424-8247