Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl <i>s</i>-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) <i>via</i> EGFR/PI3K/AKT/mTOR Signaling Cascades

• Main Authors: Ihab Shawish (Author), Assem Barakat (Author), Ali Aldalbahi (Author), Walhan Alshaer (Author), Fadwa Daoud (Author), Dana A. Alqudah (Author), Mazhar Al Zoubi (Author), Ma'mon M. Hatmal (Author), Mohamed S. Nafie (Author), Matti Haukka (Author), Anamika Sharma (Author), Beatriz G. de la Torre (Author), Fernando Albericio (Author), Ayman El-Faham (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we described the synthesis of novel pyrazole-<i>s</i>-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with <i>N</i>,<i>N</i>-dimethylfo...