Identification of 2,4-Di-<i>tert</i>-Butylphenol as an Antimicrobial Agent Against <i>Cutibacterium acnes</i> Bacteria from Rwandan Propolis
Background/Objectives: Acne is the most prevalent dermatological condition among humans, affecting approximately 80% of adolescents during puberty. To date, numerous compounds have been used for acne treatment, including erythromycin ointments and antiseptics, with varying degrees of success. The em...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2024-11-01T00:00:00Z.
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| Summary: | Background/Objectives: Acne is the most prevalent dermatological condition among humans, affecting approximately 80% of adolescents during puberty. To date, numerous compounds have been used for acne treatment, including erythromycin ointments and antiseptics, with varying degrees of success. The emergence of erythromycin-resistant <i>C. acnes</i> strains has spurred the search for new antimicrobial agents, particularly from natural sources. Methods: Propolis collected in Rwanda was extracted and fractionated by flash chromatography and tested against <i>C. acnes</i> growth by using NCLSI recommendations. Results: In our research, we identified a molecule, 2,4-Di-<i>tert</i>-butylphenol (2,4-DTBP) which inhivbited the <i>C. acnes</i> growth at a concentration of 16 µg/mL. Based on these results, we formulated an ointment (1%) using OFAP18 and petroleum jelly for the potential treatment of acne using a mouse model. Conclusions: In vitro and in vivo evidence suggests that 2,4-DTBP has anti-inflammatory properties and could effectively manage the overgrowth of <i>C. acnes</i> as well as serve as a potent alternative for the formulation of an active propolis ointment for acne treatment. |
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| Item Description: | 10.3390/antibiotics13111080 2079-6382 |