EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS

• Main Authors: L.V. Slogotskaya (Author), Ya.A. Kochetkov (Author), O.Yu. Senchikhina (Author)
• Format: Book
• Published: "Paediatrician" Publishers LLC, 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Skin tuberculin Mantoux test is widely used for the revelation of latent tuberculosis infection (LTI). Low specificity of the test (high rate of false-positive reactions due to the cross-sensitizing to vaccine strain Mycobacterium bovis BCG) results in difficulties in its interpretation. New method of LTI and active tuberculosis diagnostics is Diaskintest; it contains proteins CFP 10 and ESAT 6 which are absent in genome of M. bovis BCG and in most non-tuberculosis mycobacteria. The article presents results of a study of diagnostical value of Diaskintest (0.2 mkg/0.1 ml) and Mantoux test (with 2 TU PPD-L) in adolescents who had contacted with patients with tuberculosis. 143 adolescents from 2 colleges were examined, Diaskintest was performed in all of them, Mantoux test - in 131 patients, X-ray imaging including computer tomography - in all patients. Diaskintest demonstrated high sensitivity and specificity in diagnostics of tuberculosis in adolescents who had a contact with infected persons. 77.9% had positive Mantoux test (102/131), 5.6% - positive Diaskintest (8/143). Diaskintest revealed 5 cases of tuberculosis and 3 cases of LTI.Key words: adolescents, tuberculosis, Mantoux test, Diaskintest, diagnostics.(Voprosy sovremennoi pediatrii - Current Pediatrics. 2011; 10 (3): 70-75)

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1682-5527
1682-5535