EFFECTIVENESS OF NEW SKIN TEST (DIASKINTEST) IN REVELATION OF INFECTED ADOLESCENTS WHO HAD A CONTACT WITH PATIENTS WITH TUBERCULOSIS

• Asıl Yazarlar: L.V. Slogotskaya (Yazar), Ya.A. Kochetkov (Yazar), O.Yu. Senchikhina (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: "Paediatrician" Publishers LLC, 2011-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.
• Notes: 1682-5527; 1682-5535
• Keywords: Pediatrics; RJ1-570
• Source: Вопросы современной педиатрии, Vol 10, Iss 3 (2011)

Skin tuberculin Mantoux test is widely used for the revelation of latent tuberculosis infection (LTI). Low specificity of the test (high rate of false-positive reactions due to the cross-sensitizing to vaccine strain Mycobacterium bovis BCG) results in difficulties in its interpretation. New method of LTI and active tuberculosis diagnostics is Diaskintest; it contains proteins CFP 10 and ESAT 6 which are absent in genome of M. bovis BCG and in most non-tuberculosis mycobacteria. The article presents results of a study of diagnostical value of Diaskintest (0.2 mkg/0.1 ml) and Mantoux test (with 2 TU PPD-L) in adolescents who had contacted with patients with tuberculosis. 143 adolescents from 2 colleges were examined, Diaskintest was performed in all of them, Mantoux test - in 131 patients, X-ray imaging including computer tomography - in all patients. Diaskintest demonstrated high sensitivity and specificity in diagnostics of tuberculosis in adolescents who had a contact with infected persons. 77.9% had positive Mantoux test (102/131), 5.6% - positive Diaskintest (8/143). Diaskintest revealed 5 cases of tuberculosis and 3 cases of LTI.Key words: adolescents, tuberculosis, Mantoux test, Diaskintest, diagnostics.(Voprosy sovremennoi pediatrii - Current Pediatrics. 2011; 10 (3): 70-75)