Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as o...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2023-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the development of age-related diseases. In fact, damage due to oxidation depends strongly on the inherited or acquired defects of the redox-mediated enzymes. Molecular hydrogen (H<sub>2</sub>) has recently been reported to function as an anti-oxidant and anti-inflammatory agent for the treatment of several oxidative stress and aging-related diseases, including Alzheimer's, Parkinson's, cancer and osteoporosis. Additionally, H<sub>2</sub> promotes healthy aging, increases the number of good germs in the intestine that produce more intestinal hydrogen and reduces oxidative stress through its anti-oxidant and anti-inflammatory activities. This review focuses on the therapeutic role of H<sub>2</sub> in the treatment of neurological diseases. This review manuscript would be useful in knowing the role of H<sub>2</sub> in the redox mechanisms for promoting healthful longevity. |
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| Item Description: | 10.3390/antiox12050988 2076-3921 |