Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier
The aim of this study was to design and evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic carrier. These binary solid dispersions were prepared at varying drug loadings using the solvent evaporation method. The samples were...
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| Format: | Book |
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University of Huddersfield Press,
2023-12-01T00:00:00Z.
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| Summary: | The aim of this study was to design and evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic carrier. These binary solid dispersions were prepared at varying drug loadings using the solvent evaporation method. The samples were evaluated for their in vitro dissolution, and solid-state properties. There was over 350% increase in dissolution rate of CBZ in samples containing at least 50% POX. This study concludes that POX is an effective hydrophilic carrier for poorly soluble drugs in solid dispersions. |
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| Item Description: | 10.5920/bjpharm.1371 2058-8356 |