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Efficacy and Safety of Oral Neomycin for the Decolonization of Carbapenem-Resistant <i>Enterobacterales</i>: An Open-Label Randomized Controlled Trial

Background: Patients with carbapenem-resistant <i>Enterobacterales</i> (CRE) in the gastrointestinal (GI) tract are at risk for subsequent infections and transmission, necessitating contact precautions. Neomycin has shown in vitro activity against CRE in 66-85% of isolates. This study ev...

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Main Authors: Lalita Tancharoen (Author), Ananya Srisomnuek (Author), Surapee Tiengrim (Author), Narisara Thamthaweechok (Author), Teerawit Tangkorskul (Author), Visanu Thamlikitkul (Author)
Format: Book
Published: MDPI AG, 2024-08-01T00:00:00Z.
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Summary:Background: Patients with carbapenem-resistant <i>Enterobacterales</i> (CRE) in the gastrointestinal (GI) tract are at risk for subsequent infections and transmission, necessitating contact precautions. Neomycin has shown in vitro activity against CRE in 66-85% of isolates. This study evaluated the efficacy and safety of neomycin for CRE decolonization. Methods: In this open-label randomized controlled trial, stool/rectal swab samples from high-risk patients were collected and tested for CRE colonization in the GI tract. Patients who had CRE and met eligible criteria were divided into a neomycin group (<i>n</i> = 26; treated with 4.2 g/day neomycin for 5 days) and a control group (<i>n</i> = 26). CRE detection in stool/rectal swabs was performed on days 7 ± 2 and 14 ± 2. Results: The two groups' baseline characteristics were similar. CRE presence on day 7 ± 2 was significantly lower in the neomycin group (46.2%) than in the control group (80.8%, <i>p</i> = 0.01). Efficacy of neomycin (4.2 g/day for 5 days) for CRE decolonization was 42.8-53.8% by day 7. By day 14 ± 2, the CRE rate in the neomycin group had risen to align with the control group's rate (73.1% vs. 61.5%, <i>p</i> = 0.56). The neomycin group experienced mild, temporary, gastrointestinal side-effects. Conclusions: Neomycin effectively reduced CRE colonization on day 7 ± 2, but its impact waned by day 14 ± 2. This suggests that neomycin dosage was too low and the duration of treatment was too short for lasting CRE decolonization.
Item Description:10.3390/antibiotics13080781
2079-6382

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