Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

• Main Authors: Chang Xu (Author), Danli Peng (Author), Jialu Li (Author), Meihua Chen (Author), Yujie Hu (Author), Mingliang Hou (Author), Qingjuan Shang (Author), Qi Liang (Author), Jie Li (Author), Wenfeng Li (Author), Xiaoli Wu (Author), Changbao Liu (Author), Wanle Hu (Author), Mao Cai (Author), Huxiang Zhang (Author), Guorong Chen (Author), Lingling Yu (Author), Xiaoqun Zheng (Author), Feizhao Jiang (Author), Ju Luan (Author), Shengnan Jin (Author), Chunming Ding (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Detection of somatic mutations in tumor tissues helps to understand tumor biology and guide treatment selection. Methods such as quantitative PCR can analyze a few mutations with high efficiency, while next generation sequencing (NGS) based methods can analyze hundreds to thousan...