Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation

• প্রধান লেখক: Marine Tournissac (লেখক), Philippe Bourassa (লেখক), Ruben D. Martinez-Cano (লেখক), Tra-My Vu (লেখক), Sébastien S. Hébert (লেখক), Emmanuel Planel (লেখক), Frédéric Calon (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2019-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: Old age is associated with a rise in the incidence of Alzheimer's disease (AD) but also with thermoregulatory deficits. Indicative of a link between the two, hypothermia induces tau hyperphosphorylation. The 3xTg-AD mouse model not only develops tau and amyloid pathologies in the bra...