The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30...

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Main Authors: Sandra Augusta de Moura LEITE (Author), Rosana Costa CASANOVAS (Author), Vandilson Pinheiro RODRIGUES (Author), Adriana de Fátima Vasconcelos PEREIRA (Author), Teresa Cristina Alves FERREIRA (Author), Flávia Raquel Fernandes do NASCIMENTO (Author), Johnny Ramos do NASCIMENTO (Author), Isaac Suzart GOMES-FILHO (Author), Marcus Gomes BASTOS (Author), Antonio Luiz Amaral PEREIRA (Author)
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Published: Sociedade Brasileira de Pesquisa Odontológica.
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001 doaj_0bd7ee35ec06442e9c6556d2e8c5aa7c
042 |a dc 
100 1 0 |a Sandra Augusta de Moura LEITE  |e author 
700 1 0 |a Rosana Costa CASANOVAS  |e author 
700 1 0 |a Vandilson Pinheiro RODRIGUES  |e author 
700 1 0 |a Adriana de Fátima Vasconcelos PEREIRA  |e author 
700 1 0 |a Teresa Cristina Alves FERREIRA  |e author 
700 1 0 |a Flávia Raquel Fernandes do NASCIMENTO  |e author 
700 1 0 |a Johnny Ramos do NASCIMENTO  |e author 
700 1 0 |a Isaac Suzart GOMES-FILHO  |e author 
700 1 0 |a Marcus Gomes BASTOS  |e author 
700 1 0 |a Antonio Luiz Amaral PEREIRA  |e author 
245 0 0 |a The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels 
260 |b Sociedade Brasileira de Pesquisa Odontológica. 
500 |a 1807-3107 
500 |a 10.1590/1807-3107bor-2019.vol33.0055 
520 |a Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, high-sensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters. 
546 |a EN 
690 |a Chronic Periodontitis 
690 |a Hepcidins 
690 |a Iron 
690 |a Inflammation 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Brazilian Oral Research, Vol 33 
787 0 |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242019000100250&lng=en&tlng=en 
787 0 |n https://doaj.org/toc/1807-3107 
856 4 1 |u https://doaj.org/article/0bd7ee35ec06442e9c6556d2e8c5aa7c  |z Connect to this object online.