Cytokine production but lack of proliferation in peripheral blood mononuclear cells from chronic Chagas' disease cardiomyopathy patients in response to T. cruzi ribosomal P proteins.

• Main Authors: Silvia A Longhi (Author), Augusto Atienza (Author), Graciela Perez Prados (Author), Alcinette Buying (Author), Virginia Balouz (Author), Carlos A Buscaglia (Author), Radleigh Santos (Author), Laura M Tasso (Author), Ricardo Bonato (Author), Pablo Chiale (Author), Clemencia Pinilla (Author), Valeria A Judkowski (Author), Karina A Gómez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC). It is well known that these antibodies alter the beating rate of cardiomyocytes and provoke apoptosis by their interaction with β1-adre...