Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma

• Main Authors: Bracken Michael B (Author), Holford Theodore R (Author), Belanger Kathleen D (Author), Triche Elizabeth W (Author), Zhu Yong (Author), Gent Janneane F (Author), Pettigrew Melinda M (Author), Leaderer Brian P (Author)
• Format: Book
• Published: BMC, 2006-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>Otitis media is one of the most common infections of early childhood. Surfactant protein A functions as part of the innate immune response, which plays an important role in preventing infections early in life. This prospective study utilized a candidate gene approach to evaluate the association between polymorphisms in loci encoding SP-A and risk of otitis media during the first year of life among a cohort of infants at risk for developing asthma.</p> <p>Methods</p> <p>Between September 1996 and December 1998, women were invited to participate if they had at least one other child with physician-diagnosed asthma. Each mother was given a standardized questionnaire within 4 months of her infant's birth. Infant respiratory symptoms were collected during quarterly telephone interviews at 6, 9 and 12 months of age. Genotyping was done on 355 infants for whom whole blood and complete otitis media data were available.</p> <p>Results</p> <p>Polymorphisms at codons 19, 62, and 133 in SP-A1, and 223 in SP-A2 were associated with race/ethnicity. In logistic regression models incorporating estimates of uncertainty in haplotype assignment, the 6A⁴/1A⁵haplotype was protective for otitis media among white infants in our study population (OR 0.23; 95% CI 0.07,0.73).</p> <p>Conclusion</p> <p>These results indicate that polymorphisms within SP-A loci may be associated with otitis media in white infants. Larger confirmatory studies in all ethnic groups are warranted.</p>

Item Description

10.1186/1471-2350-7-68
1471-2350