The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure

• Main Authors: Zi-jian Xie (Author), Joel Novograd (Author), Yaakov Itzkowitz (Author), Ariel Sher (Author), Yosef D. Buchen (Author), Komal Sodhi (Author), Nader G. Abraham (Author), Joseph I. Shapiro (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This review summarizes data from several laboratories that have demonstrated a role of the Na/K-ATPase, specifically its α1 subunit, in the generation of reactive oxygen species (ROS) via the negative regulator of Src. Together with Src and other signaling proteins, the Na/K-ATPase forms an oxidant...